Photobiomodulation as the First Disease-Modifying Therapy for Hashimoto Thyroiditis
By Dr. Angela Mazza, DO, ABAARM, FAAMFM, ECNU, CDE

Special thanks to Aspen Laser

Introduction: A New Horizon in Autoimmune Thyroid Disease
Hashimoto thyroiditis (HT) is the most common autoimmune endocrine disorder in the world—and one of the most frustrating for patients and clinicians alike. Affecting an estimated 14–20 million Americans, Hashimoto’s gradually destroys thyroid tissue through chronic lymphocytic inflammation, oxidative stress, and progressive fibrosis. For decades, the medical community has approached this condition with one main tool: thyroid hormone replacement. While levothyroxine effectively normalizes laboratory values, it does nothing to halt the autoimmune attack, restore thyroid structure, reduce antibody burden, or improve tissue health.
This leaves millions of patients symptomatic and discouraged, even when their labs read as “normal.” Fatigue, brain fog, weight changes, cold intolerance, mood disturbances, and metabolic dysfunction persist in up to 40% of individuals despite appropriate thyroid hormone dosing. The discrepancy between biochemical euthyroidism and ongoing clinical suffering highlights a central truth: Hashimoto’s is not merely a hormone deficiency—it is a progressive autoimmune and tissue disease.
Dr. Angela Mazza, a nationally recognized integrative endocrinologist, believes it is time to elevate thyroid care beyond hormone replacement and into the era of true disease modification. Based on her experience, advanced imaging collaborations, and deep understanding of endocrine immunology, she proposes a bold scientific direction: Photobiomodulation (red and near-infrared light therapy) may be the first realistic, non-pharmacologic therapy capable of modifying the course of Hashimoto thyroiditis at its root.The
Science Behind Near Infrared Laser Therapy:
Why Red Light Has a Unique Role in Thyroid Health**
Photobiomodulation (PBMT), including red and near-infrared (NIR) light therapy, uses specific wavelengths (typically 600–1100 nm) to stimulate cellular repair, reduce inflammation, and restore physiologic function. Unlike ablative lasers or heating devices, PBMT works at low power densities, initiating photochemical—not thermal—reactions within cells.
The thyroid gland is uniquely suited to benefit from PBMT for several reasons:
1. High Mitochondrial Density
Thyroid follicular cells are among the most metabolically active cells in the body. PBMT directly stimulates cytochrome c oxidase within mitochondria, leading to:
· Increased ATP production
· Enhanced cellular energy metabolism
· Improved oxygen use
· Restoration of injured or dysfunctional cells
A gland dependent on mitochondrial-driven hormone synthesis is ideally positioned to respond positively to PBMT.
2. Reduction of Oxidative Stress
Hashimoto’s is characterized by heightened oxidative stress—partly because the thyroid uses hydrogen peroxide (H₂O₂) to create hormones, and partly because autoimmune inflammation generates excess reactive oxygen species (ROS).
PBMT has been shown to:
·
· Activate the body’s natural antioxidant enzymes
· Reduce oxidative injury within thyroid tissue
This helps protect thyroid follicles from continued immune-mediated destruction.
3. Immune Modulation
Hashimoto’s involves an overactivation of Th1 and Th17 immune pathways and impaired T-regulatory (Treg) function. PBMT has demonstrated:
· Downregulation of NF-κB (a major inflammatory switch)
· Reduction of pro-inflammatory cytokines (IL-6, TNF-α, IL-1β)
· Increased Treg activity and improved immune tolerance
· Shift from M1 to M2 macrophages, promoting resolution instead of damage
This is precisely the type of immune correction needed in HT.
4. Improved Microcirculation
Lack of microvascular flow contributes to tissue inflammation and impaired healing. PBMT stimulates nitric oxide release and angiogenesis, improving perfusion and allowing nutrients, oxygen, and immune-calming factors to reach damaged tissue.
5. Potential Reversal of Fibrosis
Long-standing Hashimoto’s causes fibrosis and architectural distortion visible on ultrasound. PBMT has shown the ability to regulate collagen turnover, reduce fibroblast overactivity, and promote structural recovery—an unprecedented outcome in thyroid disease.
Evidence Supporting PBMT in Hashimoto’s
Although relatively new in thyroid medicine, PBMT already has promising published evidence:
· A 2010 pilot study showed improved thyroid echogenicity, reduced antibodies, and measurable improvements on ultrasound.
· A 2013 randomized, placebo-controlled trial demonstrated improved thyroid function and reduced levothyroxine requirements in a significant portion of treated participants.
· A 2018 longitudinal study found sustained benefits up to 6 years post-treatment, including improved thyroid architecture and, in some cases, maintained euthyroidism without medication.
· A 2022 systematic review concluded that PBMT is safe, biologically plausible, and shows consistent signals of benefit—yet emphasized the need for larger, properly designed clinical trials.
While early-stage, these findings support Dr. Mazza’s premise that PBMT may be the first intervention capable of altering the natural history of Hashimoto thyroiditis.
Why Current Thyroid Care Is Not Enough
The standard treatment approach—monitoring labs and adjusting medication—fails to address:
· Ongoing autoimmune destruction
· Tissue-level inflammation and fibrosis
· Vascular stagnation
· Mitochondrial dysfunction
· Antibody persistence
Adjunctive interventions such as selenium, myo-inositol, dietary changes, or low-dose naltrexone can provide incremental support but do not stop or reverse disease progression. The result is a clinical gap: patients remain symptomatic because the underlying disease remains unaddressed.
PBMT may finally offer a tool to intervene where endocrine medicine has historically been unable to act.
Dr. Mazza’s Vision: A
Disease-Modifying Future for Thyroid Care
Dr. Mazza proposes a groundbreaking clinical trial that integrates:
· Red/NIR photobiomodulation
· High-resolution ultrasound
· Elastography for fibrosis analysis
· Vascular Doppler assessment
· Thyroid antibodies and hormone panels
· Clinical symptom scoring
This holistic, multimodal assessment merges endocrine science with state-of-the-art imaging to evaluate PBMT’s capacity to restore thyroid health—not just manage symptoms.Her vision is clear:
“Hashimoto’s has never had a true disease-modifying therapy. Photobiomodulation may be the first treatment capable of changing the trajectory of thyroid autoimmunity.”
This study aims to produce the most comprehensive thyroid PBMT dataset ever
generated in the
Advantages for PBMT Developers
Manufacturers stand to gain:
1. Clinical Validation for Expanded Indications
A successful trial supports FDA considerations, clinical claims, and broader adoption.
2. Entry Into a Multi-Million-Patient Market
Thyroid disease affects 1 in 8 women and is one of the most undertreated autoimmune disorders.
3. Differentiation in a Competitive PBMT Industry
Being the first device validated for autoimmune thyroiditis establishes unmatched market leadership.
4. High-Visibility Clinical Exposure
Results will be shared through medical conferences, scientific publications, and national education initiatives.
Conclusion:
Lighting the Path to a New Standard of Care
Hashimoto thyroiditis has remained a clinical paradox: highly prevalent, deeply impactful, yet medically underserved. Hormone replacement manages symptoms, but does not change the underlying autoimmune disease. With photobiomodulation, Dr. Mazza sees the possibility of a true shift—a therapy that addresses mitochondrial health, inflammation, microcirculation, oxidative stress, and tissue integrity all at once.
This theory is grounded in strong scientific rationale, supported by emerging evidence, and guided by clinical experience. If validated, PBMT could become the first-ever treatment capable of modifying the course of Hashimoto thyroiditis.
For device innovators and PBMT manufacturers, this is not just an
opportunity—it is a chance to participate in a transformative movement in
thyroid medicine.
The light that photobiomodulation delivers may very well become the light that
leads millions of patients to lasting, meaningful healing.
P A R T 2
THE
EYE WITHIN UNLOCKING
THE HIDDEN LANGUAGE OF MEDICAL IMAGING By: Lennard M. Goetze, Ed.D In an age when medical imaging technologies grow more advanced by the day, one truth remains unchanged: a scan is only as valuable as the mind interpreting it. The Eye Within pulls back the curtain on the art and science of diagnostic interpretation through the career and insights of Dr. Robert Bard—internationally recognized cancer imaging specialist, educator, and pioneer in ultrasound diagnostics. This is not a book about machines; it is about mastery. Dr. Bard takes readers into the high-stakes environment of medical imaging, where detecting a shadow, reading a flow pattern, or recognizing a subtle shift in tissue texture can change a life. With clarity and precision, he explains how ultrasound—when wielded by an experienced interpreter—becomes more than a tool for capturing anatomy. It becomes a dynamic instrument for understanding disease behavior, predicting progression, and guiding treatment. From evaluating elusive thyroid disorders to identifying aggressive cancers others might miss, Dr. Bard demonstrates the power of seeing beyond the image. His work exemplifies how structural detail, physiologic clues, and contextual patient information combine into a complete diagnostic picture. At its heart, The Eye Within is both an education and a call to action—urging the medical community to value interpretation as a central pillar of care. For clinicians, students, and health advocates, it is a masterclass in precision medicine. For patients, it is reassurance that in the right hands, every image tells a story—and the right interpreter knows exactly how to read it. Copyright © 2025- Hummingbird Medical Press / Lennard Goetze Publications. All rights reserved. |
READING BETWEEN THE ECHOES
Dr. Bard Reviews Dr. Mazza's Thyroid Ultrasound Scans
Introduction – The Eye That Reads Beyond the Image
In the evolving landscape of diagnostic imaging, technology has made
breathtaking advances. Yet, as Dr. Robert Bard often reminds all his
colleagues, “It’s not the probe, but the interpreter, that saves the
patient.”
Ultrasound has become a preferred frontline tool
for thyroid evaluation, particularly for identifying nodules, monitoring
autoimmune conditions like Hashimoto’s disease, and managing hyperactive
disorders such as Even in an era of AI-assisted imaging, this skill remains irreplaceable. Artificial intelligence can catalog shapes and colors, but it cannot yet replicate the human ability to weigh anatomical nuance, integrate patient history, evaluate the tumor’s ecosystem, and make forward-looking predictions. Interpretation—true interpretation—blends technology, clinical reasoning, and physiological understanding.
Dr. Angela Mazza introduces her scans of a patient, touring us into the THYROIDSCAN process. Below are are Dr. Bard’s own notes, presented in the first person, refined for clarity and depth, reflecting his approach as both a diagnostician and educator.
Assessment
1: NODULES
![]() |
| Click to enlarge |
I begin with the skin layer clearly visible at the top, followed by the anterior neck musculature and, deeper, the thyroid itself. The lesion’s borders are smooth—always a favorable sign—and I see no suspicious microcalcifications. While microcalcifications are nonspecific, their presence can indicate tissue degeneration from rapid tumor growth and poor vascular supply. Here, the echo pattern is heterogeneous, meaning the texture varies within the nodule, which warrants closer review. Of particular academic interest is the posterior wall brightness—dimmer than the anterior—reflecting sound absorption by solid tissue. This “through transmission” loss can signal dense or heterogeneous pathology and is an important interpretive clue.
![]() |
| Click to enlarge |
This image shows
a well-circumscribed, cystic structure. The posterior border is brighter than
the anterior because fluid allows sound to pass freely. Internal debris is
visible—common in benign cysts and observable with high-resolution probes.
Surrounding tissues are neither compressed nor invaded, suggesting no
aggressive behavior. This is a prime example of strong through transmission, a
useful differentiator between cystic and solid pathology.
![]() |
| Click to enlarge |
This lesion exhibits both solid and cystic components, the most common benign thyroid pattern but also possible in malignancies. The posterior border is again brighter due to the fluid component. On the left, I note the common carotid artery—its wall smooth and without plaque. When scanning thyroids, I always evaluate adjacent structures; lymph nodes and vessels often provide indirect clues to pathology.
![]() |
| Click to enlarge |
Here, the anterior and posterior borders are similar in brightness, suggesting limited fluid content. The heterogeneous echo texture and a small calcification at the cystic-solid interface may represent tumor degeneration. It’s important to remember that tumor enlargement during therapy does not always indicate progression—degenerating tumors can swell with fluid before shrinking.
![]() |
| Click to enlarge |
The lesion contains cystic and solid areas separated by septations, giving it a spongiform appearance. The macrocalcification is consistent with degenerative change. The bright posterior border confirms significant cystic degeneration—what I refer to as “internal cystic necrosis”—often a sign of tumor breakdown.
Assessment
#2: THYROID CANCER
![]() |
| Click to enlarge |
In this case, credit must be given to Dr. Angela Mazza for her precise capture of a lesion demonstrating classic hallmarks of thyroid cancer. High-quality image acquisition is not accidental—it reflects an operator’s ability to optimize probe selection, angulation, and focal depth to reveal the lesion’s most telling features. This provides the interpreting radiologist with the complete visual data needed for an accurate assessment. One such feature is the presence of microcalcifications—tiny, punctate echogenic foci within the lesion. While not exclusively diagnostic of cancer, their occurrence often signals abnormal cellular turnover and tissue degeneration, making them an important red flag in the radiologist’s assessment.
A second hallmark is the firm, rigid texture of malignant tissue. I often describe it to students using the “steel analogy”: just as steel resists penetration, cancerous tissue offers a gritty, unyielding resistance to a biopsy needle. This hardness correlates with the tumor’s dense cellular structure and fibrotic reaction. Equally significant is the taller-than-wide dimension ratio. Benign nodules, when they grow, tend to expand laterally, developing smooth, encapsulated borders. Aggressive cancers, however, often invade vertically, crossing tissue planes. This vertical dominance is a subtle but critical diagnostic cue—used not only in thyroid cancer but also in breast oncology.
On ultrasound, malignancies typically appear hypoechoic—darker than the surrounding thyroid parenchyma—because the dense cellular mass absorbs more sound energy, allowing less to be reflected back to the transducer. This also results in a posterior acoustic shadow or a dimmer back border, further reinforcing the suspicion of a solid, infiltrative process. When these elements—microcalcifications, firmness, hypoechogenicity, vertical growth, and diminished posterior transmission—are observed together, they form a constellation of findings that strongly favor malignancy. The role of the interpreting radiologist is not simply t note these features, but to integrate them into a complete risk profile for each patient, guiding both urgency and strategy in clinical management.
Assessment
3: HASHIMOTO’S
& GRAVES DISEASE
![]() |
| Click to enlarge |
Hashimoto’s presents variably on ultrasound—sometimes uniform in echotexture, sometimes showing fibrotic stranding and mixed internal patterns. Routine thyroid blood panels can miss autoimmune-mediated inflammation, making ultrasound a critical adjunct. The gland may reveal fibrotic bands, patchy echogenic change, or small cystic areas depending on the stage of degeneration. In this case, the echo pattern is mixed, with no significant change in rear-wall brightness compared to normal thyroid tissue. Because through-transmission may remain unaltered, interpretation must be integrated with autoimmune-specific serology, patient symptoms, and disease history to achieve a confident diagnosis and guide long-term management.
![]() |
| Click to enlarge |
Although Graves’ disease is not a form of cancer, it remains a significant thyroid condition because of its system-wide effects and marked increase in glandular blood flow. The overproduction of thyroid hormones accelerates metabolism across multiple organ systems, influencing cardiovascular function, skin changes, and general physiological balance. In grayscale (B-mode) ultrasound, the thyroid often presents with a uniform appearance, though areas of patchy irregularity from fibrotic change may be visible. Through-transmission typically mirrors that of normal tissue; however, the clearest diagnostic distinction emerges when color Doppler imaging is applied.
Under Doppler, Graves’ disease can display a pronounced surge in intrathyroidal vascularity, with smooth, branching blood vessels feeding an overactive gland. This striking visual signature—sometimes described as a “thyroid inferno”—serves not only as an identifier of disease activity but also as a guide for therapy. By following these vascular patterns over time, clinicians can fine-tune treatment plans and adjust dosages without invasive biopsies or radioactive scans.
THERMOLOGY:
THE STRATEGIC FIRST STEP IN THYROID IMAGING
Before an ultrasound probe touches the skin, thermographic imaging can create a dynamic map of the thyroid’s physiologic activity. By detecting infrared heat patterns from the skin surface, thermology reveals areas of abnormal vascular activity—whether from inflammation, autoimmune flare, or tumor-driven angiogenesis. This non-contact, radiation-free technique serves as an early “scout,” directing the sonographer’s focus to regions most likely to harbor disease.
In skilled hands, this dual-modality approach—thermology for physiologic mapping and ultrasound for structural definition—offers a fast, noninvasive, and highly precise pathway for diagnosis, monitoring, and personalized thyroid care.
CONCLUSION – A PARTNERSHIP IN PRECISION
Dr. Bard’s review of Dr. Angela Mazza’s thyroid ultrasound cases demonstrates why expertise in interpretation remains indispensable. Every scan is more than an image—it is a layered narrative of structure, function, and evolving physiology. By coupling her deep endocrinology expertise with ultrasound as a primary diagnostic tool, Dr. Mazza ensures her patients receive assessments that are both scientifically rigorous and dynamically responsive.
In an age where algorithms threaten to overshadow human judgment, this collaboration underscores an enduring truth: the best outcomes emerge when skilled imaging interpretation meets the informed clinical context of a specialist who understands the whole patient.
This article draft is an original work produced by the writing and editorial team of the AngioInstitute (a 501(c)(3) nonprofit organization), created exclusively for use, distribution, and publication by DetoxScan.org. All content contained herein, including written material, concepts, titles, and formatting, is the intellectual property of the AngioInstitute and is protected under United States and international copyright laws. Unauthorized reproduction, copying, distribution, transmission, or republication of any portion of this material—whether in print, digital, or any other format—is strictly prohibited without prior written permission from the copyright holder. The AngioInstitute retains full ownership of the content until and unless formally transferred in writing. This draft may not be altered, adapted, or used in derivative works without express consent. All rights reserved. For inquiries regarding usage, permissions, or content licensing, please contact the AngioInstitute directly.


.jpg)




























